(2-Methyl-4-(N-methylsulfamoyl)phenyl)boronic acid - Names and Identifiers
(2-Methyl-4-(N-methylsulfamoyl)phenyl)boronic acid - Physico-chemical Properties
Molecular Formula | C8H12BNO4S
|
Molar Mass | 229.06 |
Storage Condition | 2-8°C |
Sensitive | IRRITANT |
MDL | MFCD13195666 |
(2-Methyl-4-(N-methylsulfamoyl)phenyl)boronic acid - Introduction
(2-Methyl-4-(N-methylsulfamoyl)phenyl)boronic acid, also known as (2-Methyl-4-(N-methylsulfamoyl)phenyl)boronic acid, is an organic boron compound. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: White to yellow solid
-Molecular formula: C9H13BNO4S
-Molecular weight: 255.13g/mol
-melting point: 197-199 ℃
-Solubility: Soluble in some organic solvents such as dimethyl sulfoxide and dichloromethane, slightly soluble in alcohols and ketones, slightly soluble in water.
Use:
- (2-Methyl-4-(N-methylsulfamoyl)phenyl)boronic acid is commonly used as a boric acid derivative of aromatic compounds in organic synthesis for C- C bond formation and C- O bond formation reactions.
-It can be used to prepare medicines, dyes and other organic compounds.
-In the field of medicine, it is also used in the research and preparation of pharmaceutical formulations.
Preparation Method:
(2-Methyl-4-(N-methylsulfamoyl)phenyl) The preparation of boronic acid is usually achieved by organic synthesis methods, and the specific steps are as follows:
1. First, (2-methyl -4-methylaminophenyl) boronic acid in xylene is reacted with methanesulfonyl chloride to produce (2-methyl -4-(methylsulfonyl) phenyl) boronic acid.
2. then, under alkaline conditions, N-methylmethylsulfonamide is added to the compound generated in the first step to generate the final product (2-Methyl-4-(N-methylsulfamoyl)phenyl)boronic acid through nucleophilic substitution reaction.
Safety Information:
- (2-Methyl-4-(N-methylsulfamoyl)phenyl)boronic acid is relatively safe under general conditions of use, but it is still necessary to comply with laboratory safety procedures.
-Avoid contact with skin and eyes during use, and ensure that it is operated in a well-ventilated environment.
-Seek immediate medical attention if taken by mistake or if touched, inhaled or ingested.
-During storage, try to avoid long-term contact with oxidants, acids, alkalis and other substances, and keep them dry.
Please note that when using and handling any chemical substances, you should strictly follow laboratory safety procedures and follow appropriate safety measures.
Last Update:2024-04-09 21:01:54